用各种免疫原增强大鼠肾同种异体移植。

Enhancement of rat renal allografts with various immunogens.

作者信息

Martin D C, Hewitt C W

出版信息

Invest Urol. 1981 Mar;18(5):406-8.

Abstract

Lewis rat recipients of Brown Norway (BN) and Dark Agouti (DA) kidneys were tested for enhanced survival after they were injected with various immunogens. Lewis recipients of BN kidneys injected with either BN whole blood, bone marrow cells, red blood cells, or DA whole blood had enhanced survival. Lewis recipients of BN kidneys injected with either BN plasma or BN thymocytes did not have enhanced survival. Lewis recipients of DN kidneys injected with DA blood had enhanced survival. Lymphocytotoxins were found infrequently in recipients with rejected renal allografts. Active enhancement of the rat renal graft may be produced by immunization with cells that express serum determined or cell determined antigens.

摘要

对接受了棕色挪威（BN）和黑褐（DA）肾脏的Lewis大鼠注射各种免疫原后，检测其生存时间是否延长。接受BN肾脏的Lewis大鼠注射BN全血、骨髓细胞、红细胞或DA全血后，生存时间延长。接受BN肾脏的Lewis大鼠注射BN血浆或BN胸腺细胞后，生存时间未延长。接受DA肾脏的Lewis大鼠注射DA血液后，生存时间延长。在移植肾被排斥的受体中，很少发现淋巴细胞毒素。用表达血清决定或细胞决定抗原的细胞进行免疫，可能会主动增强大鼠肾移植的效果。

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