Pack A I, DeLaney R G, Fishman A P
J Appl Physiol Respir Environ Exerc Physiol. 1981 Jan;50(1):149-61. doi: 10.1152/jappl.1981.50.1.149.
Studies were conducted in anesthetized paralyzed dogs using a cycle-triggered constant-flow ventilator, which ventilated the animal in phase with the recorded phrenic neural activity. Intermittently tests were performed in which the animal was ventilated with a different airflow for a single breath. Increased airflows, within the range generated during spontaneous breathing, caused an increased rate of rise of the moving average phrenic neurogram and a shortening of the duration of the nerve burst. The magnitude of the increase in the rate of rise of the neurogram was related to the level of inspiratory airflow. Tests with brief pulses of airflow showed that an increase in the rate of rise of the phrenic neurogram could be produced without inflating the lung above the resting tidal volume of the animal. Similar results were obtained with negative-pressure ventilation and the effects were abolished by vagotomy. This vagally mediated augmentation of phrenic neural output may accelerate the inspiratory volume change in the lung during spontaneous breathing at hyperpneic levels.
研究在麻醉瘫痪的狗身上进行，使用循环触发恒流呼吸机，该呼吸机根据记录的膈神经活动同步对动物进行通气。间歇性地进行测试，让动物用不同的气流进行单次呼吸通气。在自主呼吸产生的气流范围内增加气流，会导致移动平均膈神经图的上升速率增加，以及神经冲动持续时间缩短。神经图上升速率增加的幅度与吸气气流水平有关。用短暂气流脉冲进行的测试表明，在不使肺充气超过动物静息潮气量的情况下，也可使膈神经图的上升速率增加。负压通气也得到了类似结果，且迷走神经切断术可消除这些影响。这种由迷走神经介导的膈神经输出增强，可能会在呼吸急促时的自主呼吸过程中加速肺内吸气容积的变化。
