Peterson M E, Nesbitt G H, Schaer M
J Am Vet Med Assoc. 1981 Jan 1;178(1):66-9.
Concurrent diabetes mellitus and hyperadrenocorticism were diagnosed in 30 dogs over a 2-year period. Clinical signs included polyuria, hepatomegaly, polyphagia, abdominal distension, truncal alopecia, anorexia, and vomiting. Because of the similar clinical and laboratory findings for hyperadrenocorticism and diabetes mellitus, hyperadrenocorticism was initially overlooked in some dogs. Insulin resistance, characterized by high daily insulin requirements, developed in the diabetic dogs with untreated hyperadrenocorticism. Therapy with o,p'-DDD resulted in precipitous declines in insulin requirements. By lowering the dosage of o,p'-DDD and supplementing with glucocorticoids during the o,p'-DDD loading period, serious hypoglycemia was avoided. Control of coexisting hyperadrenocorticism lessened the severity of the diabetes mellitus, but insulin therapy remained a necessity in all dogs.
在两年时间里，30只犬被诊断出同时患有糖尿病和肾上腺皮质功能亢进。临床症状包括多尿、肝肿大、多食、腹胀、躯干脱毛、厌食和呕吐。由于肾上腺皮质功能亢进和糖尿病的临床及实验室检查结果相似，一些犬最初被忽视了肾上腺皮质功能亢进。未治疗肾上腺皮质功能亢进的糖尿病犬出现了以每日胰岛素需求量高为特征的胰岛素抵抗。使用邻对滴滴涕治疗导致胰岛素需求量急剧下降。在邻对滴滴涕负荷期通过降低邻对滴滴涕剂量并补充糖皮质激素，避免了严重低血糖。控制并存的肾上腺皮质功能亢进减轻了糖尿病的严重程度，但所有犬仍需胰岛素治疗。
