Gillespie W J, Mayo K M
J Bone Joint Surg Br. 1981 Feb;63-B(1):126-31. doi: 10.1302/0301-620X.63B1.7009619.
The outcome of primary management of acute osteomyelitis in 655 children treated in New Zealand between 1947 and 1976 is examined. Failure occurred in 20 per cent of children, in four-fifths of whom it was manifest by one year, and half of whom experienced one recurrence only. Lower failure rates were associated with use of bactericidal antibiotics, certain favourable sites, and age over 16 years. Surgical intervention was associated with significantly higher failure rates. The place of surgical intervention and the optimal duration of antibiotic treatment can only be determined by prospective clinical trials.
对1947年至1976年间在新西兰接受治疗的655名儿童急性骨髓炎的初始治疗结果进行了检查。20%的儿童治疗失败，其中五分之四在1年内出现失败表现，且一半儿童仅经历1次复发。较低的失败率与使用杀菌抗生素、某些有利部位以及16岁以上的年龄有关。手术干预与显著更高的失败率相关。手术干预的作用和抗生素治疗的最佳持续时间只能通过前瞻性临床试验来确定。
