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[人类肾移植后第三发性甲状旁腺功能亢进。甲状旁腺切除及自体移植治疗。8例(作者译)]

[Tertiary hyperparathyroidism after renal transplantation in man. Treatment by parathyroidectomy and auto-graft. Eight cases (author's transl)].

作者信息

Tanguy G, Soulillou J P, Visset J, Thoulouzan E, Le Bodic M F, Guenel J

出版信息

J Chir (Paris). 1981 Jan;118(1):39-44.

PMID:7009626
Abstract

In a series of 76 functional renal transplantations we noted 8 cases of hyperparthyroidism occurring in periods ranging from 2 months to 4 years. Hypercalcaemia was the most constant manifestation. PTH was raised in the 7 subjects in whom it was measured. Eight patients underwent total parathyroidectomy followed in 7 of them by auto-graft of a fragment of parathyroid into a forearm muscle according to the technique of Wells. The operation was followed in all cases by normalisation in blood calcium levels after the 1st month. Serum PTH levels also returned to normal apart from in one case where renal function was impaired because of rejection of the renal graft. Comparative estimations of PTH in venous blood from the side of the auto-graft and the opposite side showed that the parathyroid graft was functioning.

摘要

在一组76例功能性肾移植病例中,我们注意到8例甲状旁腺功能亢进,发病时间从2个月至4年不等。高钙血症是最常见的表现。在检测的7名受试者中,甲状旁腺激素(PTH)升高。8例患者接受了甲状旁腺全切术,其中7例根据韦尔斯技术将甲状旁腺碎片自体移植到前臂肌肉中。术后所有病例在第1个月后血钙水平恢复正常。除1例因肾移植排斥导致肾功能受损外,血清PTH水平也恢复正常。对自体移植侧和对侧静脉血中PTH的比较评估表明,甲状旁腺移植物发挥了功能。

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