Gross M D, Grekin R J, Brown L E, Marsh D D, Beierwaltes W H
J Clin Endocrinol Metab. 1981 Apr;52(4):612-5. doi: 10.1210/jcem-52-4-612.
Dexamethasone suppression adrenal scintigraphy is routinely used in the clinical assessment of patients with aldosteronism. To determine the relation between adrenal iodocholesterol uptake and aldosterone secretory activity, iodocholesterol uptake in dexamethasone-suppressed dogs was measured during salt loading and salt depletion. Sodium loading resulted in decreases in both serum aldosterone and adrenal iodocholesterol uptake. Sodium depletion was associated with increases in both serum aldosterone and iodocholesterol uptake. From these studies we calculate that under basal conditions, approximately 10% of adrenal iodocholesterol uptake is angiotension dependent, and approximately 50% is ACTH dependent. The administration of dexamethasone results in an increase in the sensitivity of adrenal scintiscanning in the assessment of adrenal zona glomerulosa function.
地塞米松抑制肾上腺闪烁扫描术常用于醛固酮增多症患者的临床评估。为确定肾上腺碘胆固醇摄取与醛固酮分泌活性之间的关系，在盐负荷和盐缺乏期间测量了地塞米松抑制的犬的碘胆固醇摄取。钠负荷导致血清醛固酮和肾上腺碘胆固醇摄取均降低。钠缺乏与血清醛固酮和碘胆固醇摄取增加有关。从这些研究中我们计算出，在基础条件下，约10%的肾上腺碘胆固醇摄取依赖于血管紧张素，约50%依赖于促肾上腺皮质激素。地塞米松的给药导致在评估肾上腺球状带功能时肾上腺闪烁扫描的敏感性增加。
