Satoh S, Fujisawa S, Tanaka R, Nakai K
Jpn J Pharmacol. 1980 Aug;30(4):515-9. doi: 10.1254/jjp.30.515.
The effects of captopril administered intravenously in a dose of 1 mg/kg on systemic blood pressure (SBP), renal blood flow (RBF) and renal vascular resistance (RVR) were examined in pentobarbital anesthetized dogs. Untreated dogs were used in experiments in which the renal artery remained intact and others in which the renal artery was partially occluded (RAO). Captopril significantly decreased SBP, increased RBF and decreased RVR in untreated dogs. RAO induced an increase in arterial plasma renin activity and this increase was accompanied by an increase in RVR in the contralateral kidney and rise in SBP. During RAO, captopril induced qualitatively similar, but greater decreases in SBP and RVR of the contralateral kidney compared with those in the untreated dogs. These results suggest the vasodilator effect of captopril depends on the background level of angiotensin II and the enhanced effect would be expected under conditions such as RAO where circulating angiotensin II contributes to vascular tone.
在戊巴比妥麻醉的犬中，研究了静脉注射剂量为1mg/kg的卡托普利对全身血压（SBP）、肾血流量（RBF）和肾血管阻力（RVR）的影响。实验使用了未治疗的犬，其中一部分犬肾动脉保持完整，另一部分犬肾动脉部分闭塞（RAO）。在未治疗的犬中，卡托普利显著降低SBP，增加RBF并降低RVR。RAO导致动脉血浆肾素活性增加，这种增加伴随着对侧肾脏RVR的增加和SBP的升高。在RAO期间，与未治疗的犬相比，卡托普利使对侧肾脏的SBP和RVR产生了性质相似但更大程度的降低。这些结果表明，卡托普利的血管舒张作用取决于血管紧张素II的基础水平，并且在诸如RAO等循环血管紧张素II有助于血管张力的情况下，预期会有增强作用。
