Kihlström E
Scand J Infect Dis Suppl. 1980;Suppl 24:141-3.
Monolayers of HeLa cells were treated with lipopolysaccharide (LPS) or alkali-treated lipopolysaccharide (aLPS) from Salmonella typhimurium 395 MS (wild) and MR10 (chemotype Rd), and the effects on subsequent adhesion of MS and R10 bacteria determined. R10 LPS increased the adhesion of both R10 and MS bacteria; more so for R10. MS aLPS increased the adhesion of R10 bacteria and to some extent of MS. MS LPS and R10 aLPS had only small effects. Significant inhibition of bacterial adhesion could not be found with any of the LPS preparations used. aLPS had greater affinity than LPS for HeLa cells. HeLa cells did not lose viability after treatment with LPS or aLPS. These results indicate that LPS and aLPS may change the properties of the HeLa cell surface and expose areas amenable to interact with bacteria.
用来自鼠伤寒沙门氏菌395 MS（野生型）和MR10（化学型Rd）的脂多糖（LPS）或碱处理的脂多糖（aLPS）处理单层HeLa细胞，并测定其对随后MS和R10细菌粘附的影响。R10 LPS增加了R10和MS细菌的粘附；对R10的增加更明显。MS aLPS增加了R10细菌的粘附，并在一定程度上增加了MS的粘附。MS LPS和R10 aLPS的影响很小。使用的任何LPS制剂均未发现对细菌粘附的显著抑制作用。aLPS比LPS对HeLa细胞具有更高的亲和力。HeLa细胞在用LPS或aLPS处理后没有丧失活力。这些结果表明，LPS和aLPS可能会改变HeLa细胞表面的特性，并暴露出易于与细菌相互作用的区域。
