Donahue T F, Farabaugh P J, Fink G R
Science. 1981 Apr 24;212(4493):455-7. doi: 10.1126/science.7010605.
Five ICR-170--induced mutations at the His4 locus in yeast are +1 G.C (G, guanine; C, cytosine) additions in DNA regions that contain multiple G.C base pairs. These mutations represents both nonsuppressible and suppressible alleles. All externally, suppressible frameshift mutations occur in glycine and proline codons to produce the four-base codons GGGU (U, uracil), GGGG, and CCCU. This implies that suppression of these four-base codons in yeast, as in bacteria, involves a four-base anticodon or its functional equivalent. Two identical four-base codons (CCCU) at widely separate regions with His4 are not suppressed equally.
酵母中组氨酸4位点的五个ICR - 170诱导突变是在含有多个鸟嘌呤 - 胞嘧啶（G.C）碱基对的DNA区域中添加了 +1 G.C（G代表鸟嘌呤；C代表胞嘧啶）。这些突变代表了不可抑制和可抑制的等位基因。所有外部可抑制的移码突变都发生在甘氨酸和脯氨酸密码子中，以产生四碱基密码子GGGU（U代表尿嘧啶）、GGGG和CCCU。这意味着酵母中这些四碱基密码子的抑制，如同在细菌中一样，涉及一个四碱基反密码子或其功能等效物。在组氨酸4基因座广泛分离区域的两个相同的四碱基密码子（CCCU）受到的抑制并不相同。
