Montgomery R R, Ducore J M, Githens J H, August C S, Johnson M L
Transplantation. 1980 Aug;30(2):90-6. doi: 10.1097/00007890-198008000-00002.
Treatment of acquired aplastic anemia with androgens has been occasionally associated with the development of hepatic tumors. We have studied a 13-year-old boy with idiopathic aplastic anemia in whom oxymetholone treatment was associated with a partial hematological remission. Thirty-four months later, however, the patient developed multiple hepatic tumors. When oxymetholone therapy was discontinued, the aplastic anemia relapsed. He then underwent bone marrow transplantation from his HLA-A, B, and D-compatible sibling. This was followed by hematological and immunological reconstitution. The hepatic tumors underwent progressive regression after bone marrow transplantation. The patient is now 3 years post-bone marrow transplantation and is in complete remission of his aplastic anemia with no evidence of detectable liver tumors.
使用雄激素治疗获得性再生障碍性贫血偶尔会伴有肝肿瘤的发生。我们研究了一名13岁患有特发性再生障碍性贫血的男孩，他使用羟甲烯龙治疗后血液学部分缓解。然而，34个月后，该患者出现了多发性肝肿瘤。停用羟甲烯龙治疗后，再生障碍性贫血复发。随后他接受了来自其HLA - A、B和D位点相合的同胞的骨髓移植。移植后实现了血液学和免疫学重建。骨髓移植后肝肿瘤逐渐消退。现在该患者已进行骨髓移植3年，再生障碍性贫血完全缓解，未发现可检测到的肝肿瘤迹象。
