Andersen J, Aabro E, Gulmann N, Hjelmsted A, Pedersen H E
Acta Neurol Scand. 1980 Oct;62(4):210-9. doi: 10.1111/j.1600-0404.1980.tb03028.x.
Nineteen patients with L-DOPA treated parkinsonism involving depressive symptoms, the therapeutic effect of nortriptyline was compared to placebo in a controlled trial. The depressive and neurological symptoms were evaluated by rating scales. Nortriptyline had a clinical significant effect with regard to the depressive symptoms, whereas the neurological parameters were unchanged. The authors suggest the depression in Parkinson's disease to be of both reactive and endogenous origins.
19例接受左旋多巴治疗且伴有抑郁症状的帕金森病患者，在一项对照试验中比较了去甲替林与安慰剂的治疗效果。通过评定量表评估抑郁和神经症状。去甲替林对抑郁症状有显著临床疗效，而神经参数未改变。作者认为帕金森病中的抑郁既有反应性起源也有内源性起源。
