Calissendorff B, Marén N, Wettrell K, Ostberg A
Acta Ophthalmol (Copenh). 1980 Aug;58(4):624-31. doi: 10.1111/j.1755-3768.1980.tb08304.x.
Fifty-eight patients with intraocular hypertension or primary open angle glaucoma participated in a double masked randomized study. Timolol in concentrations 0.25% and 0.5% was compared with 1, 2, or 4% pilocarpine Acetazolamide (250 mg x 3) was added if intraocular pressure (IOP) was uncontrolled with the highest concentrations tested. No statistical difference was found in hypotensive effect between pilocarpine and timolol neither on ocular hypertensions nor glaucomas. The additive hypotensive effect of acetazolamide was the same for both substances. Once a day by administration of timolol was sufficient in 17 of 20 cases controlled merely by topical administration.
58例高眼压症或原发性开角型青光眼患者参与了一项双盲随机研究。将0.25%和0.5%浓度的噻吗洛尔与1%、2%或4%的毛果芸香碱进行比较。如果在测试的最高浓度下眼压（IOP）仍未得到控制，则加用乙酰唑胺（250mg×3）。毛果芸香碱和噻吗洛尔在降低眼压方面，无论是对高眼压症还是青光眼，均未发现统计学差异。乙酰唑胺对这两种药物的降压增效作用相同。仅通过局部用药控制的20例患者中，有17例每天使用一次噻吗洛尔就足够了。
