Axelrod A E
Adv Exp Med Biol. 1981;135:93-106. doi: 10.1007/978-1-4615-9200-6_5.
Studies conducted in our laboratory relating to the development of immune processes in B vitamin deficiency states of experimental animals have been reviewed. 1. The significant participation of certain of these nutritional factors in the production of circulating antibodies to a variety of antigens and the manifestation of delayed hypersensitivity reactions, including the rejection of tissue transplants, have been described. 2. Investigations on the mode of action of pyridoxine and pantothenic acid have demonstrated a marked reduction in the production of antibody-forming cells following antigenic stimulation in both deficiency states. The metabolism of antigen appeared to be normal. However, these two vitamins seem to function at different loci in the development of the immune process. Whereas pyridoxine appears to be necessary for the production of "C1" units from serine which are required for the biosynthesis of nucleic acids, it seems likely that pantothenic acid is involved in the secretion of newly-synthesized proteins into the extracellular compartment.
我们实验室开展的有关实验动物维生素B缺乏状态下免疫过程发展的研究已被综述。1. 已描述了其中某些营养因子在针对多种抗原产生循环抗体以及迟发型超敏反应（包括组织移植排斥反应）表现中的重要参与情况。2. 对吡哆醇和泛酸作用方式的研究表明，在这两种缺乏状态下，抗原刺激后抗体形成细胞的产生均显著减少。抗原的代谢似乎正常。然而，这两种维生素在免疫过程发展中似乎作用于不同位点。鉴于吡哆醇对于从丝氨酸生成核酸生物合成所需的“C1”单位似乎是必需的，泛酸似乎参与了新合成蛋白质向细胞外区室的分泌。
