Howard C P, Takahashi H, Hayles A B
Am J Dis Child. 1981 Apr;135(4):326-8. doi: 10.1001/archpedi.1981.02130280016006.
The effectiveness of a combination of somatropin (0.1 IU/kg in three doses per week) and oxandrolone (0.1 mg/kg/day) in the treatment of human growth hormone deficiency was evaluated. Twelve children with hypopituitarism were placed into two separate groups. Each group was treated for five 6-month periods, and anthropologic measurements and bone-age determinations were obtained at the end of each period. Both groups of children grew approximately 20 cm during the 30 months of treatment. Somatropin increased the growth rate significantly both when given alone and when given in combination with oxandrolone. Although the addition of oxandrolone may have diminished the waning effect often seen during somatropin therapy, the acceleration in bone age indicates the need for further long-term studies before oxandrolone can be recommended as an adjunct to treatment with somatropin.
评估了生长激素（每周三次，每次0.1 IU/kg）与氧雄龙（0.1 mg/kg/天）联合使用治疗人生长激素缺乏症的有效性。12名垂体功能减退的儿童被分为两个独立的组。每组接受五个6个月疗程的治疗，并在每个疗程结束时进行人体测量和骨龄测定。两组儿童在30个月的治疗期间身高均增长了约20厘米。生长激素单独使用或与氧雄龙联合使用时均显著提高了生长速率。虽然添加氧雄龙可能减弱了生长激素治疗期间常见的疗效减弱现象，但骨龄加速表明在推荐氧雄龙作为生长激素治疗的辅助药物之前，需要进一步进行长期研究。
