Ingemarsson I, Westgren M, Lindberg C, Ahrén B, Lundquist I, Carlsson C
Am J Obstet Gynecol. 1981 Mar 15;139(6):697-701. doi: 10.1016/0002-9378(81)90489-0.
Maternal and fetal blood glucose and insulin levels were studied in 10 women in the second stage of labor after administration of terbutaline, 250 micrograms intravenously. The transport of the drug across the placenta was also studied. Saline solution was administered to four other women who served as controls. A rise in maternal plasma insulin levels occurred in all patients but was more pronounced in patients treated with terbutaline less than 25 minutes before delivery than in those treated more than 45 minutes prior to delivery. No difference was found in maternal blood glucose levels between terbutaline-treated patients and controls. Blood glucose increased in the fetuses during the second stage of labor and paralleled that of the mothers, but on a lower level. None of the newborn infants demonstrated hypoglycemia during the first 90 minutes after birth. Terbutaline crossed the placenta rapidly, and fetal plasma levels up to 55% of the maternal plasma levels were found. The conclusion is that this form of administration of terbutaline does not seem to have any negative short-term influences on the fetal carbohydrate metabolism.
对10名在静脉注射250微克特布他林后进入第二产程的妇女的母血和胎儿血糖及胰岛素水平进行了研究。还研究了该药物通过胎盘的转运情况。另外4名妇女接受生理盐水注射作为对照。所有患者的母体血浆胰岛素水平均升高，但在分娩前不到25分钟接受特布他林治疗的患者中比在分娩前45分钟以上接受治疗的患者中更为明显。特布他林治疗组患者与对照组的母体血糖水平无差异。在第二产程中胎儿血糖升高，且与母体血糖平行，但水平较低。在出生后的前90分钟内，没有新生儿出现低血糖。特布他林能迅速通过胎盘，胎儿血浆水平可达母体血浆水平的55%。结论是，这种特布他林给药方式似乎对胎儿碳水化合物代谢没有任何短期负面影响。
