Gusman B S, Vul'fovich Iu V, Kagan G Ia
Arkh Patol. 1980;42(12):26-32.
Histological, histochemical, and immunofluorescent methods were used to study alterations in the hearts of 250 randombred white mice inoculated once intraperitoneally with a stable culture of L-forms of beta-hemolytic group A streptococcus in a dose of 2 x 10(6) CFU and sacrificed at intervals of 1 day to 1 year after inoculation. The development of chronic progressive pathological process (inflammatory, dystrophic, and sclerotic) involving all the membranes of the heart and running against an increasing allergic background was demonstrated. In connective tissue formations of the heart, the antigen of streptococcus L-forms could be detected by immunofluorescence throughout the duration of the experiment. The observed pathogenicity of streptococcus L-forms indicates the necessity of elucidating their role in human infectious pathology.
采用组织学、组织化学和免疫荧光方法，研究了250只随机繁殖的白色小鼠的心脏变化。这些小鼠经腹腔一次性接种剂量为2×10⁶CFU的A组β溶血性链球菌L型稳定培养物，并在接种后1天至1年的间隔时间处死。结果表明，心脏所有膜层均出现慢性进行性病理过程（炎症、营养不良和硬化），且该过程在过敏背景不断增强的情况下发生。在整个实验过程中，通过免疫荧光可在心脏结缔组织形成物中检测到链球菌L型抗原。观察到的链球菌L型致病性表明有必要阐明它们在人类感染病理学中的作用。
