使用噻美尼定和可乐定治疗期间及治疗后血压、血浆儿茶酚胺和血浆肾素活性的变化。
Changes in blood pressure, plasma catecholamines and plasma renin activity during and after treatment with tiamenidine and clonidine.
作者信息
Hansson B G, Hökfelt B
出版信息
Br J Clin Pharmacol. 1981 Jan;11(1):73-7. doi: 10.1111/j.1365-2125.1981.tb01105.x.
Abstract
1 Tiamenidine (Hoe 440) is an imidazoline with blood pressure lowering properties. Its pharmacology resembles that of clonidine. 2 The effect of both drugs on blood pressure, plasma noradrenaline (NA), plasma adrenaline (Ad), urinary catecholamines and plasma renin activity (PRA) was assessed in four previously untreated male hypertensive patients in a cross over study. 3 The maximum daily dose of tiamenidine was 3 mg. The maximum daily dose of clonidine was 450 micrograms. 4 During treatment, blood pressure, systolic and diastolic, supine and erect, fell on average between 12 and 15%. Levels of NA, Ad, PRA were reduced during treatment. 5 During withdrawal of either drug there was rebound of blood pressure and NA, Ad, PRA, overshooting baseline levels. 6 The withdrawal effects caused by clonidine were similar for tiamenidine.
摘要
- 噻美尼定（Hoe 440）是一种具有降压特性的咪唑啉。其药理作用与可乐定相似。2. 在一项交叉研究中，对4名未经治疗的男性高血压患者评估了这两种药物对血压、血浆去甲肾上腺素（NA）、血浆肾上腺素（Ad）、尿儿茶酚胺和血浆肾素活性（PRA）的影响。3. 噻美尼定的最大日剂量为3毫克。可乐定的最大日剂量为450微克。4. 治疗期间，仰卧位和直立位的收缩压和舒张压平均下降12%至15%。治疗期间NA、Ad、PRA水平降低。5. 在停用任何一种药物期间，血压以及NA、Ad、PRA出现反跳，超过基线水平。6. 可乐定引起的撤药效应与噻美尼定相似。
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本文引用的文献
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