冷球蛋白、循环免疫复合物与脑型疟疾中的补体激活
Cryoglobulins, circulating immune complexes, and complement activation in cerebral malaria.
作者信息
Adam C, Géniteau M, Gougerot-Pocidalo M, Verroust P, Lebras J, Gibert C, Morel-Maroger L
出版信息
Infect Immun. 1981 Feb;31(2):530-5. doi: 10.1128/iai.31.2.530-535.1981.
A total of 32 patients with Plasmodium falciparum malaria were studied. Of these, 23 had benign infections, and 9 had typical cerebral malaria. Cryoglobulins, circulating immune complexes detected by a C1q-binding assay, and hypocomplementemia were found in eight of nine patients with cerebral malaria. Raised levels of complement component 3 breakdown products (C3d) were found in the seven patients tested. Peak levels of circulating immune complexes and C3d were associated with thrombocytopenia. In contrast, in patients with benign Plasmodium falciparum malaria, cryoglobulins and circulating immune complexes were found only in 3 of 23 patients. Similarly, hypocomplementemia was detected only in 5 of 23 patients. These observations suggest that the intensity of the immune response and of the associated complement activation may be important factors in the pathogenesis of cerebral malaria.
共研究了32例恶性疟原虫疟疾患者。其中，23例为良性感染，9例为典型脑型疟疾。在9例脑型疟疾患者中，有8例检测到冷球蛋白、通过C1q结合试验检测的循环免疫复合物和补体低下。在接受检测的7例患者中发现补体成分3裂解产物（C3d）水平升高。循环免疫复合物和C3d的峰值水平与血小板减少有关。相比之下，在良性恶性疟原虫疟疾患者中，仅23例中有3例检测到冷球蛋白和循环免疫复合物。同样，仅23例中有5例检测到补体低下。这些观察结果表明，免疫反应强度及相关补体激活可能是脑型疟疾发病机制中的重要因素。
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