脲酶在感染性结石形成中的作用：不同来源脲酶的比较
Role of urease in the formation of infection stones: comparison of ureases from different sources.
作者信息
Rosenstein I J, Hamilton-Miller J M, Brumfitt W
出版信息
Infect Immun. 1981 Apr;32(1):32-7. doi: 10.1128/iai.32.1.32-37.1981.
Abstract
Bacterial and vegetable ureases were found to differ in certain important respects. For maximal clinical relevance, in vitro studies on the pathogenic role of urease should use whole bacterial cells of Proteus spp., and urease inhibitors should be assessed without preincubation of enzyme with inhibitor. Urease from Proteus morganii was very different from ureases of other species of Proteus; this factor should be taken into account when infections with P. morganii are being treated.
摘要
人们发现细菌脲酶和植物脲酶在某些重要方面存在差异。为了使体外研究在临床方面具有最大相关性，关于脲酶致病作用的体外研究应使用变形杆菌属的完整细菌细胞，并且在评估脲酶抑制剂时，不应将酶与抑制剂预先孵育。摩根氏变形杆菌的脲酶与其他变形杆菌属物种的脲酶非常不同；在治疗摩根氏变形杆菌感染时应考虑到这一因素。
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本文引用的文献
1
An improved selective medium for the formation of ascospores by Aspergillus nidulans.一种用于构巢曲霉形成子囊孢子的改良选择性培养基。
Nature. 1962 Mar 17;193:1106. doi: 10.1038/1931106a0.
2
Hepatic coma.
Annu Rev Med. 1960;11:47-58. doi: 10.1146/annurev.me.11.020160.000403.
3
UREASE CATALYSIS. II. INHIBITION OF THE ENZYME BY HYDROXYUREA, HYDROXYLAMINE, AND ACETOHYDROXAMIC ACID.脲酶催化作用。II. 羟基脲、羟胺和乙酰氧肟酸对该酶的抑制作用。
J Biol Chem. 1965 Jun;240:2407-14.
4
UREASE CATALYSIS. I. STOICHIOMETRY, SPECIFICITY, AND KINETICS OF A SECOND SUBSTRATE: HYDROXYUREA.脲酶催化作用。I. 第二种底物：羟基脲的化学计量、特异性和动力学
J Biol Chem. 1965 Jun;240:2402-6.
5
Specific inhibition of urease by hydroxamic acids.异羟肟酸对脲酶的特异性抑制作用。
Biochim Biophys Acta. 1962 Dec 4;65:380-3. doi: 10.1016/0006-3002(62)91067-3.
6
The effect of acetohydroxamic acid on the induction of bacterial ureases.乙酰氧肟酸对细菌脲酶诱导的影响。
Invest Urol. 1980 Sep;18(2):112-4.
7
Some properties and purifications of urease.
Biochim Biophys Acta. 1967 Sep 12;146(1):205-18. doi: 10.1016/0005-2744(67)90087-3.
8
Proteus vulgaris urease: in vitro inhibition by urea analogues.普通变形杆菌脲酶：尿素类似物的体外抑制作用
Proc Soc Exp Biol Med. 1966 Jun;122(2):506-8. doi: 10.3181/00379727-122-31174.
9
Acetohydroxamate: bacterial urease inhibitor with therapeutic potential in hyperammonaemic states.
Nature. 1965 Oct 2;208(5005):46-8. doi: 10.1038/208046a0.
10
Inhibition of urease by metal ions.
Enzymologia. 1969 Jun 30;36(6):332-4.
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