Taylor R E, Blatt P M
J Am Acad Dermatol. 1981 Mar;4(3):348-68. doi: 10.1016/s0190-9622(81)70035-5.
Abnormal bleeding or bruising is frequently encountered in the clinical practice of dermatology. A working knowledge of mechanisms of normal hemostasis, a complete history (general, bleeding, familial), a thorough physical examination, and an appropriate laboratory evaluation are the integral steps in the diagnostic process. Cutaneous bruising and/or bleeding may be a manifestation of a previously unrecognized hereditary coagulation deficiency such as mild hemophilia or von Willebrand's disease (vWD), hereditary or acquired qualitative or quantitative platelet disorder, disturbance of the vascular or supporting structure, or it may be due to one of several acquired systemic disorders.
在皮肤科临床实践中,经常会遇到异常出血或瘀伤的情况。了解正常止血机制、完整的病史(一般情况、出血情况、家族史)、全面的体格检查以及适当的实验室评估是诊断过程中不可或缺的步骤。皮肤瘀伤和/或出血可能是先前未被识别的遗传性凝血缺陷的表现,如轻度血友病或血管性血友病(vWD)、遗传性或获得性血小板质或量的异常、血管或支持结构的紊乱,也可能是几种获得性全身性疾病之一所致。