Francesconi M, Mörz R, Rainer H, Moser K
Onkologie. 1980 Dec;3(6):301-6. doi: 10.1159/000214811.
cis-Dichlorodiammineplatinum(II) was administered in 23 patients with far advanced solid malignancies using a dose schedule of 50 mg/m2 every 3 weeks. All patients previously had progressive disease using conventional cytotoxic therapies. More than 50% of the patients had been pretreated with at least four different drugs, 9 patients had additionally been irradiated. IN 4 patients there was objective tumor regression (duration 1-4 months); in 7 patients tumor progression could be stopped for at least 1 month; 12 patients did not respond. By sufficient fluid administration combined with electrolyte substitution, furosemide and mannitol, no severe toxic side effects were encountered.
对23例晚期实体恶性肿瘤患者使用顺二氯二氨合铂（II），给药方案为每3周50mg/m²。所有患者此前使用传统细胞毒性疗法时病情均进展。超过50%的患者曾接受至少四种不同药物的预处理，9例患者还接受过放疗。4例患者出现客观肿瘤消退（持续时间1 - 4个月）；7例患者肿瘤进展得以停止至少1个月；12例患者无反应。通过充分补液并结合电解质替代、使用呋塞米和甘露醇，未出现严重毒性副作用。
