Cobby J
J Biomed Mater Res. 1978 Sep;12(5):627-34. doi: 10.1002/jbm.820120505.
A previously derived cubic equation describing the release of drugs from matrix tablets is compared with a more complex equation recently presented. Using data obtained from cylindrical hydrocortisone matrix tablets, it is shown that the simpler cubic equation affords an equally acceptable description of drug release. Because the cubic equation contains a release-rate constant Kr that is independent of tablet shape, a congruency between this equation and other historical models of diffusion may be demonstrated. It is suggested, given the complexity of drug disposition in vivo, that simplicity in modeling is a desirable goal.
将先前推导的描述药物从骨架片中释放的三次方程与最近提出的一个更复杂的方程进行了比较。利用从圆柱形氢化可的松骨架片获得的数据表明，较简单的三次方程对药物释放的描述同样可以接受。由于三次方程包含一个与片剂形状无关的释放速率常数Kr，因此可以证明该方程与其他传统扩散模型之间具有一致性。鉴于体内药物处置的复杂性，有人提出在建模中保持简单是一个理想的目标。
