Richard G A, Iravani A, LeFrock J L, Mogabgab W
Rev Infect Dis. 1981 Jan-Feb;3(1):159-65. doi: 10.1093/clinids/3.1.159.
Orally administered bacampicillin (400 mg twice daily for 10 days) was as effective as orally administered amoxicillin (250 mg thrice daily for 10 days) for the treatment of acute, uncomplicated infections of the urinary tract in young women. A satisfactory clinical response was produced by bacampicillin in 71 (98.6%) of 72 patients and by amoxicillin in 73 (98.6%) of 74 patients. A satisfactory bacteriologic response was produced by bacampicillin in 69 (95.8%) of 72 patients and by amoxicillin in 72 (97.3%) of 74 patients. In a subset of the patients, bacampicillin and amoxicillin were equally effective in the treatment of infections of the upper and lower urinary tract, as determined by the fluorescent antibody-coated bacterial test of localization. Both bacampicillin and amoxicillin were well tolerated. Allergic skin reactions occurred in two (2.7%) of 74 patients receiving amoxicillin but in none of the patients receiving bacampicillin. Mild diarrhea occurred in two (2.8%) of 72 patients receiving bacampicillin and in two (2.7%) of 74 patients receiving amoxicillin. Bacampicillin administered twice daily may offer several advantages over drugs given three times a day (e.g., amoxicillin) or four times a day (e.g., ampicillin). These advantages might include lower cost, better compliance with treatment regimen, and fewer allergic episodes and adverse reactions.
口服巴氨西林（每日两次，每次400毫克，共10天）与口服阿莫西林（每日三次，每次250毫克，共10天）治疗年轻女性急性非复杂性尿路感染的效果相同。72例患者中，71例（98.6%）使用巴氨西林后临床反应良好；74例患者中，73例（98.6%）使用阿莫西林后临床反应良好。72例患者中，69例（95.8%）使用巴氨西林后细菌学反应良好；74例患者中，72例（97.3%）使用阿莫西林后细菌学反应良好。通过荧光抗体包被细菌定位试验测定，在部分患者中，巴氨西林和阿莫西林在上、下尿路感染的治疗中疗效相当。巴氨西林和阿莫西林的耐受性均良好。74例接受阿莫西林治疗的患者中有2例（2.7%）出现过敏性皮肤反应，而接受巴氨西林治疗的患者中未出现此类情况。72例接受巴氨西林治疗的患者中有2例（2.8%）出现轻度腹泻，74例接受阿莫西林治疗的患者中有2例（2.7%）出现轻度腹泻。与每日服用三次（如阿莫西林）或四次（如氨苄西林）的药物相比，每日服用两次的巴氨西林可能具有多种优势。这些优势可能包括成本更低、对治疗方案的依从性更好、过敏发作和不良反应更少。
