Berg B, Gunnarsson R, Lundgren G, Magnusson G, Möller E, Groth C G
Scand J Urol Nephrol Suppl. 1980;54:41-3.
Of the 320 cadaveric renal transplantations carried out between 1970 and 1978 in Stockholm 308 were analysed with respect to dependence of graft survival on HLA-A, -B matching. From November, 1973, kidneys with 3 or 4 HLA-A, -B incompatibilities were accepted much more often than had previously been the case. All but 7 of the 90 grafts with 3 or 4 incompatibilities were transplanted during that period. In order to obtain as homogeneous a group as possible the transplantations performed during this period were analysed separately, and transplantation performed on diabetic patients and retransplantations were excluded. This material comprising 141 transplantations was examined also with respect to other factors that may have a bearing on graft survival. As regards the factors mean age, pre-transplantation dialysis and blood transfusions, primary diuresis at transplantation and high-dose ALG therapy there was no essential difference between the recipients of kidneys from donors with 1 or 2 HLA-A, -B incompatibilities and the 3 or 4 incompatibility group. Thirteen of the 141 transplantations were fully compatible but because this group was small it was not included in the statistical analysis. After 2 years the group with 3 or 4 HLA-A, -B incompatibilities displayed a significantly poorer graft survival than the one with 1 or 2 incompatibilities (p less than 0.05).
1970年至1978年期间，在斯德哥尔摩进行了320例尸体肾移植手术，其中308例针对移植肾存活对HLA - A、- B配型的依赖性进行了分析。从1973年11月起，具有3个或4个HLA - A、- B不相配的肾脏被接受的频率比以前高得多。在这一时期，90例具有3个或4个不相配的移植肾中，除7例之外均在此期间进行了移植。为了获得尽可能同质的一组数据，对这一时期进行的移植手术单独进行了分析，并排除了糖尿病患者的移植手术和再次移植手术。对包含141例移植手术的这组数据，还就可能影响移植肾存活的其他因素进行了检查。关于平均年龄、移植前透析和输血、移植时的初次利尿以及高剂量抗淋巴细胞球蛋白治疗等因素，来自具有1个或2个HLA - A、- B不相配供体的肾脏受者与具有3个或4个不相配的组之间没有本质区别。141例移植手术中有13例完全相配，但由于该组样本量小，未纳入统计分析。2年后，具有3个或4个HLA - A、- B不相配的组移植肾存活率明显低于具有1个或2个不相配的组（p小于0.05）。
