Solheim B G, Flatmark A, Halvorsen S, Jervell J, Pape J, Thorsby E
Scand J Urol Nephrol Suppl. 1980;54:63-6.
The influence of pre-transplant blood transfusions and haemodialysis has been analyzed in 191 consecutive living related first transplants. A significantly increased graft survival was seen among patients having received blood transfusions and transplanted with a 1 haplotype disparate kidney, while no effect could be observed in HLA-identical transplantations. No significant effect could be detected on recipient survival. Four patients to receive 1 haplotype mis-matched grafts were sensitized against their potential donors by transfusions, and therefore not transplanted with living related donors. The frequency of first rejection episodes was highly significantly reduced in transfused compared to non-transfused 1 haplotype mis-matched transplanted patients while no influence was seen in identicals. Pretransplant haemodialysis improved graft survival, the difference was, however, only significant in the 1 haplotype mis-matched group. When analyzed for patient survival, the difference between the pre-dialytic patients and those on haemodialysis was even more pronounced. When analyzed separately, both blood transfusions and haemodialysis had a beneficial effect on graft survival.
对191例连续的活体亲属首次肾移植受者分析了移植前输血和血液透析的影响。接受过输血且移植了1个单倍型不匹配肾脏的患者，其移植肾存活率显著提高，而在 HLA 相同的移植中未观察到影响。对受者生存率未检测到显著影响。4例接受1个单倍型错配移植肾的患者因输血而对其潜在供者致敏，因此未接受活体亲属供者移植。与未输血的1个单倍型错配移植患者相比，输血患者首次排斥反应的发生率显著降低，而在 HLA 相同的移植患者中未观察到影响。移植前血液透析改善了移植肾存活率，然而，差异仅在1个单倍型错配组中显著。分析患者生存率时，透析前患者与接受血液透析患者之间的差异更为明显。单独分析时，输血和血液透析对移植肾存活率均有有益影响。
