Jakobsen A, Birkeland S A, Gäbel H, Fjeldborg O, Halvorsen S, Ladefoged J, Lundgren G, Konrad P, Wallenius M, Wikström B, Flatmark A
Scand J Urol Nephrol Suppl. 1980;54:71-5.
During the period 1965-1977, a total of 339 patients with polycystic renal disease received at least 1 renal transplant at one of 10 transplant centres in Scandinavia. Patient survival at one year was 67%. The one year graft survival of 319 cadaveric grafts was 40%. The average age of the patient was 56.7 years. Patients who were 60 years or older (93 patients) had a significantly poorer patient and graft survival at one year (50% and 29.5% respectively). Patients receiving kidneys with O incompatibilities did significantly better than other donor-recipient combinations. Previous blood transfusions were associated with better graft prognosis, though the difference was only significant for 2 years. The incidence of posttransplant urinary tract infection (present in 47% of all the patients) was twice as common in patients with a history of pretransplant urinary tract infection (seen in 41% of all the patients). There was no association between posttransplant septicaemia and either pre- or post-transplant urinary tract infection. Only 10.5% of the patients were nephrectomized at the time of transplantation, half of these had urinary tract infection. Twenty-four per cent of the patients were nephrectomized in the posttransplant period, half of these because of infection. There was no difference in the graft survival data of the patients with or without pretransplant urinary tract infection. These findings justify a restrictive practice with regard to pretransplant nephrectomy in patients with polycystic renal disease.
在1965年至1977年期间，共有339例多囊肾病患者在斯堪的纳维亚半岛的10个移植中心之一接受了至少1次肾移植。1年时的患者生存率为67%。319例尸体供肾移植的1年移植物生存率为40%。患者的平均年龄为56.7岁。60岁及以上的患者（93例）1年时的患者和移植物生存率明显较差（分别为50%和29.5%）。接受O血型不相容肾脏的患者比其他供受者组合的患者情况明显更好。既往输血与更好的移植物预后相关，不过差异仅在2年时显著。移植后尿路感染的发生率（在所有患者中占47%）在有移植前尿路感染病史的患者中是其两倍（在所有患者中占41%）。移植后败血症与移植前或移植后尿路感染均无关联。仅10.5%的患者在移植时接受了肾切除术，其中一半有尿路感染。24%的患者在移植后接受了肾切除术，其中一半是因为感染。有或没有移植前尿路感染的患者的移植物生存数据没有差异。这些发现证明对多囊肾病患者移植前肾切除术应采取限制性做法是合理的。
