Whitehill R, Hakala M W
J Bone Joint Surg Am. 1978 Sep;60(6):815-9.
In a canine experimental model, femora were lengthened 2.5 to 3.0 centimeters over a one-minute period. Systolic blood-pressure elevation averaged forty millimeters of mercury and diastolic blood-pressure elevation, twenty-two millimeters of mercury. The average peak arterial pressure was 193/115 millimeters of mercury. The effects of sympatholytic agents on the experimental model were tested. Alpha-adrenergic blockade by phenoxybenzamine, total-body catecholamine depletion by reserpine, and sympathetic ganglionic blockade by trimethaphan camphorsulfonate all inhibited the rise in arterial pressure, but beta-adrenergic blockade by propranolol did not. A differential spinal anesthetic with Xylocaine solution dramatically decreased the elevation in arterial pressure.
在一个犬类实验模型中，股骨在一分钟内被延长了2.5至3.0厘米。收缩压平均升高40毫米汞柱，舒张压升高22毫米汞柱。平均动脉压峰值为193/115毫米汞柱。测试了交感神经阻滞剂对该实验模型的影响。苯氧苄胺的α-肾上腺素能阻断、利血平的全身儿茶酚胺耗竭以及樟磺咪芬的交感神经节阻断均抑制了动脉压的升高，但普萘洛尔的β-肾上腺素能阻断则没有。用利多卡因溶液进行的选择性脊髓麻醉显著降低了动脉压的升高。
