• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

胃标志物蛋白。主细胞酯酶的纯化及免疫组织学证明。

Gastric marker proteins. Purification and immunohistological demonstration of the chief cell esterase.

作者信息

Rapp W, Wurster K

出版信息

Virchows Arch A Pathol Anat Histol. 1981;390(2):151-60. doi: 10.1007/BF02215981.

DOI:10.1007/BF02215981
PMID:7013252
Abstract

An immunogenic acid stable esterase of gastric origin was purified from normal gastric juice. Specific antibodies were obtained by solid immunoadsorbents and were used for indirect immunoenzyme histology on gastric resection specimens. This esterase proved to be a cell specific marker for gastric chief cells. Different patterns of chief cell alterations in gastritis and cancer were observed.

摘要

从正常胃液中纯化出一种源自胃的具有免疫原性且酸稳定的酯酶。通过固相免疫吸附剂获得特异性抗体，并将其用于胃切除标本的间接免疫酶组织学研究。这种酯酶被证明是胃主细胞的一种细胞特异性标志物。观察到胃炎和癌症中主细胞改变的不同模式。

相似文献

1
Gastric marker proteins. Purification and immunohistological demonstration of the chief cell esterase.胃标志物蛋白。主细胞酯酶的纯化及免疫组织学证明。
Virchows Arch A Pathol Anat Histol. 1981;390(2):151-60. doi: 10.1007/BF02215981.
2
[Clinico-diagnostic importance of antigenic gastric juice esterase. VI A. Semiquantitative, immunologic and electrophoretic enzyme demonstration].[胃蛋白酶原的临床诊断重要性。六 A. 半定量、免疫及电泳酶检测]
Klin Wochenschr. 1970 Dec 15;48(24):1441-4. doi: 10.1007/BF01484681.
3
[Pepsin isoenzymes in gastric juice from patients with cancer and other gastric disorders].[癌症及其他胃部疾病患者胃液中的胃蛋白酶同工酶]
Vopr Med Khim. 1968 Jan-Feb;14(1):71-4.
4
[Lactate dehydrogenase (LDH) activity of the gastric juice depending on the metabolic state and protective barrier of the gastric mucosa].[取决于胃黏膜代谢状态和保护屏障的胃液乳酸脱氢酶（LDH）活性]
Ter Arkh. 1978;50(10):28-30.
5
An immunological and chromatographic comparison of human intrinsic factor and the acid-stable gastric esterase VI A.人内因子与酸稳定胃酯酶VI A的免疫学及色谱分析比较
Clin Exp Immunol. 1971 Jul;9(1):11-20.
6
Intestinal metaplasia of gastric mucosa: its frequency and functional properties.胃黏膜肠化生：其发生率及功能特性
Neoplasma. 1974;21(4):455-63.
7
Relationship of beta-glucuronidase activity in gastric juice to the histology of the gastric mucosa.胃液中β-葡萄糖醛酸酶活性与胃黏膜组织学的关系。
Gastroenterology. 1970 Mar;58(3):352-7.
8
Diagnostic value of determination of lactate dehydrogenase and beta-glucuronidase activity of gastric juice. Correlation with a histologic study of the gastric mucosa.胃液乳酸脱氢酶及β-葡萄糖醛酸酶活性测定的诊断价值。与胃黏膜组织学研究的相关性。
Digestion. 1972;7(3):174-82. doi: 10.1159/000197272.
9
[On a new enzyme in human gastric juice. Immunological, electrophoretic and enzymatic characteristics of a vitamin B 12 binding carboxylesterase, isolated from gastric mucosa].[关于人胃液中的一种新酶。从胃黏膜分离出的维生素B₁₂结合羧酸酯酶的免疫学、电泳和酶学特性]
Klin Wochenschr. 1967 May 15;45(10):533-41. doi: 10.1007/BF01716372.
10
[Comparative data on the activity of gastric proteolytic enzymes in pathological states of the stomach including cancer].[关于胃蛋白酶解酶在包括癌症在内的胃部病理状态下活性的比较数据]
Klin Lech Zlokach Novoobraz. 1968;11:15-7.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
EVALUATION OF NORMAL GASTRIC MUCOSAL ANTIGENS AND ENZYMES IN CANCEROUS HUMAN GASTRIC MUCOSA BY AGAR-AND IMMUNO-ELECTROPHORESIS.琼脂免疫电泳法对人胃癌组织中正常胃黏膜抗原及酶的评估
Int Arch Allergy Appl Immunol. 1965;26:327-32. doi: 10.1159/000229585.
3
THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION.
胃癌的两种主要组织学类型：弥漫型和所谓的肠型癌。组织学临床分类的尝试。
Acta Pathol Microbiol Scand. 1965;64:31-49. doi: 10.1111/apm.1965.64.1.31.
4
CONSTITUENTS AND ANTIGENS OF NORMAL HUMAN GASTRIC MUCOSA AS CHARACTERIZED BY ELECTROPHORESIS AND IMMUNOELECTROPHORESIS IN AGAR GEL.琼脂凝胶电泳和免疫电泳表征的正常人胃黏膜的成分与抗原
J Immunol. 1964 Apr;92:579-95.
5
Histochemistry of the gastric mucosa.胃黏膜的组织化学
Gut. 1963 Mar;4(1):68-76. doi: 10.1136/gut.4.1.68.
6
Histochemical study of the distribution of esterases.酯酶分布的组织化学研究
J Histochem Cytochem. 1953 Nov;1(6):471-85. doi: 10.1177/1.6.471.
7
The normal human gastric epithelia. A fine structural study.正常人体胃上皮。一项超微结构研究。
Lab Invest. 1968 Dec;19(6):598-626.
8
Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads.通过亲和色谱法进行蛋白质纯化。琼脂糖和聚丙烯酰胺珠粒的衍生化。
J Biol Chem. 1970 Jun;245(12):3059-65.
9
Human gastric antigens. I. The purification and preliminary characterization of the antigenic, acid-stable carboxyl esterase VI A.人胃抗原。I. 抗原性、酸稳定羧基酯酶VI A的纯化及初步特性分析
Eur J Clin Invest. 1972 Jun;2(4):243-9. doi: 10.1111/j.1365-2362.1972.tb00651.x.
10
An immunological and chromatographic comparison of human intrinsic factor and the acid-stable gastric esterase VI A.人内因子与酸稳定胃酯酶VI A的免疫学及色谱分析比较
Clin Exp Immunol. 1971 Jul;9(1):11-20.