Jonderko G, Sobczyk P, Gabryel A, Marcisz C, Niedziela-Pokrzyk A
Z Gesamte Inn Med. 1981 Feb 1;36(3):79-82.
Investigations were carried out on two groups of patients suffering from cyclophrenia, atypical psychosis and schizophrenia. Both groups as well as a control group consisted of 30 persons each. The first of the psychiatric groups was treated with lithium carbonate and neuroleptics during a period of time ranging from 6 months to 8 years. The second psychiatric group was treated only with neuroleptics. The following parameters were being specified: The level of cortisol, insulin, somatotropin (GH) and lithium in the blood serum and also the glucose level in blood. Furthermore, the influence of lithium carbonate upon cortisol secretion and GH after insulin stimulation was also examined. The results of our work prove that the long-lasting treatment with lithium, when proper doses are carefully chosen, does not cause any significant changes of all the examined parameters.
对两组患有循环型精神病、非典型精神病和精神分裂症的患者进行了调查。两组以及一个对照组每组均由30人组成。第一个精神科组在6个月至8年的时间内接受碳酸锂和抗精神病药物治疗。第二个精神科组仅接受抗精神病药物治疗。确定了以下参数：血清中皮质醇、胰岛素、生长激素（GH）和锂的水平以及血糖水平。此外，还研究了碳酸锂对胰岛素刺激后皮质醇分泌和GH的影响。我们的研究结果证明，当仔细选择适当剂量时，长期使用锂治疗不会导致所有检测参数发生任何显著变化。
