Zucker D K, Livingston R L, Nakra R, Clayton P J
Biol Psychiatry. 1981 Feb;16(2):197-205.
Although an association of psychiatric symptoms with vitamin B12 deficiency is well accepted, the incidence and nature of these symptoms is not established. To help illuminate the natural history of this illness we review the literature regarding psychopathology associated with B12 deficiency and examine 15 cases, including one of our own, that meet specified criteria for B12-responsive psychosis. In the accepted cases the most common psychiatric symptoms were organic brain syndrome, paranoia, violence, and depression. Several of the patients were not anemic and had no neurologic deficit. Examination of blood smears or obtaining of serum B12 levels should be considered for patients with the symptoms described.
尽管精神症状与维生素B12缺乏之间的关联已被广泛认可，但这些症状的发生率和性质尚未明确。为了有助于阐明这种疾病的自然史，我们回顾了有关与B12缺乏相关的精神病理学的文献，并检查了15例符合B12反应性精神病特定标准的病例，其中包括我们自己的1例。在已确诊的病例中，最常见的精神症状是器质性脑综合征、偏执狂、暴力行为和抑郁。其中一些患者没有贫血且没有神经功能缺损。对于出现所述症状的患者，应考虑检查血涂片或检测血清B12水平。
