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发育中人类胎儿脊髓的放射状胶质细胞:高尔基染色、免疫组织化学及电子显微镜研究

Radial glia of developing human fetal spinal cord: Golgi, immunohistochemical and electron microscopic study.

作者信息

Choi B H

出版信息

Brain Res. 1981 Apr;227(2):249-67. doi: 10.1016/0165-3806(81)90112-7.

DOI:10.1016/0165-3806(81)90112-7
PMID:7013909
Abstract

Radial glia of the developing spinal cord were examined by Golgi, electron microscopic and immunohistochemical methods in 40 human embryos and fetuses of ovulation age 6-20 weeks. As in developing cerebrum and cerebellum, gliogenesis in the spinal cord occurs much earlier than traditionally believed. The presence of transitional forms suggests that subependymal glia originate from detached radial glia that divide and differentiate in their new location. Well-differentiated astroglia evolve from radial glia as fetal age advances.

摘要

运用高尔基染色法、电子显微镜技术和免疫组织化学方法,对40例排卵龄在6至20周的人类胚胎和胎儿发育中的脊髓放射状胶质细胞进行了研究。与发育中的大脑和小脑一样,脊髓中的神经胶质生成比传统认知的要早得多。过渡形式的存在表明,室管膜下神经胶质起源于脱离的放射状胶质细胞,这些细胞在新位置进行分裂和分化。随着胎龄增加,分化良好的星形胶质细胞由放射状胶质细胞演变而来。

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