Weick R F
Can J Physiol Pharmacol. 1980 Aug;58(8):995-8. doi: 10.1139/y80-152.
A refractory period of 6-8 days following the estrogen-induced luteinizing hormone (LH) surge in the rhesus monkey has been reported, the estrogen having been applied as injections of estradiol benzoate. This was reinvestigated using Silastic capsules filled with estradiol-17-beta. Mature intact female rhesus monkeys were given two successive exposures to estrogen, each of 48 h duration. In one experiment the second exposure started 4 days after the capsules were first implanted (2 days after removal), in the second experiment, 3 days after implantation (1 day after removal). LH surges were seen in response to both estrogen treatments in both experiments. The results suggests that a period of exposure to relatively low estrogen levels is required before a second LH surge can be elicited. This period of time can be as short as 24 h.
据报道，给恒河猴注射苯甲酸雌二醇后，在雌激素诱导促黄体生成素（LH）激增后的6 - 8天存在不应期。本研究使用填充有17-β雌二醇的硅橡胶胶囊对此进行了重新调查。成熟的未交配雌性恒河猴连续两次暴露于雌激素，每次持续48小时。在一个实验中，第二次暴露在首次植入胶囊后4天（取出后2天）开始，在第二个实验中，在植入后3天（取出后1天）开始。在两个实验中，两种雌激素处理均引发了LH激增。结果表明，在第二次LH激增被引发之前，需要一段暴露于相对低雌激素水平的时间。这段时间可短至24小时。
