Wang R I, Robinson N
Clin Pharmacol Ther. 1981 Jun;29(6):771-5. doi: 10.1038/clpt.1981.109.
In a single-dose study the analgesic activity of 400 mg doxpicomine was compared with 4 and 8 mg morphine administered intramuscularly. Our subjects wee 43 men with moderate or severe postsurgical pain on the first postoperative day. Results of a double-blind trial indicate the analgesic activity of 400 mg intramuscular doxpicomine to be within the range of 8 mg morphine. There was no statistical significance between the effects of 400 mg doxpicomine and 8 mg morphine with the exception of half-hour data where doxpicomine was more effective than morphine. Doxpicomine has a rapid onset of analgesic action, the duration of which is equivalent to that of 8 mg morphine.
在一项单剂量研究中，将400毫克多匹可明的镇痛活性与肌肉注射4毫克和8毫克吗啡的镇痛活性进行了比较。我们的研究对象为43名男性，他们在术后第一天有中度或重度术后疼痛。双盲试验结果表明，肌肉注射400毫克多匹可明的镇痛活性在8毫克吗啡的范围内。400毫克多匹可明和8毫克吗啡的效果之间没有统计学意义，除了半小时的数据，此时多匹可明比吗啡更有效。多匹可明具有快速起效的镇痛作用，其持续时间与8毫克吗啡相当。
