Edwards H, Olafsson O, Hyman A I, Drusin R E, Reemtsma K
Crit Care Med. 1981 Jun;9(6):498-9. doi: 10.1097/00003246-198106000-00015.
Dopamine is commonly used to improve cardiac output and to maintain peripheral perfusion after myocardial injury. It has several advantages over other catecholamines. At effective inotropic dose levels, dopamine produces less peripheral vasoconstriction than norepinephrine. Dopamine also causes fewer arrhythmias than isoproterenol. This is a case report of a heart transplant patient who began rejecting and developed heart failure. In addition to the immunosuppressive agents, dopamine was used initially as the vasopressor with marked deterioration in the patient's condition. Dobutamine, a new inotropic agent, was substituted for dopamine with subsequent improvement in cardiac function. The authors concluded that dobutamine may be the most appropriate agent to use in the rejecting transplanted heart because of the former's direct action on the heart. Dobutamine may also be preferred for support of the cardiac outputs of patients with chronic heart failure.
多巴胺常用于改善心肌损伤后的心脏输出量并维持外周灌注。与其他儿茶酚胺相比，它有几个优点。在有效的正性肌力剂量水平下，多巴胺产生的外周血管收缩比去甲肾上腺素少。多巴胺引起的心律失常也比异丙肾上腺素少。这是一例心脏移植患者的病例报告，该患者开始出现排斥反应并发展为心力衰竭。除免疫抑制剂外，最初使用多巴胺作为血管加压药，但患者病情显著恶化。新型正性肌力药物多巴酚丁胺替代了多巴胺，随后心脏功能得到改善。作者得出结论，由于多巴酚丁胺对心脏的直接作用，它可能是用于移植心脏排斥反应的最合适药物。多巴酚丁胺也可能更适合用于支持慢性心力衰竭患者的心脏输出量。
