Reinilä A
Diabetologia. 1981 Mar;20(3):205-12. doi: 10.1007/BF00252629.
Arterial ultrastructure was examined in twelve untreated streptozotocin-diabetic rats. Five showed severe changes in muscular (coronary, tibial, pulmonary) arteries two months after induction of diabetes. The basement membrane of smooth muscle cells was patchily thickened in these arteries. No similar changes were seen in muscular arteries of the other seven diabetic rats or in 10 control rats. No lesions were found in elastic arteries (aorta, main pulmonary artery) of any diabetic or control animals. Plasma non-esterified fatty acids, total ketone bodies, and glucose levels were higher in the diabetic rats with arterial changes (p less than 0.01) than in the diabetic animals without such changes. The molar ratio of non-esterified fatty acid to albumin in plasma ranged between 2.3-3.3 in the diabetic rats with arterial lesions, 1.4-1.8 in those without such features, and 0.6-1.1 in the controls. The excess of non-esterified fatty acid in plasma during insulin deficiency could be an important factor in the initiation of arterial changes in this model of experimental diabetes.
对12只未经治疗的链脲佐菌素诱导的糖尿病大鼠的动脉超微结构进行了检查。糖尿病诱导两个月后，5只大鼠的肌性动脉（冠状动脉、胫动脉、肺动脉）出现严重变化。这些动脉中平滑肌细胞的基底膜呈片状增厚。在其他7只糖尿病大鼠的肌性动脉或10只对照大鼠的肌性动脉中未观察到类似变化。在任何糖尿病或对照动物的弹性动脉（主动脉、主肺动脉）中均未发现病变。有动脉变化的糖尿病大鼠的血浆非酯化脂肪酸、总酮体和葡萄糖水平高于无此类变化的糖尿病动物（p<0.01）。有动脉病变的糖尿病大鼠血浆中非酯化脂肪酸与白蛋白的摩尔比在2.3-3.3之间，无此类特征的大鼠在1.4-1.8之间，对照组在0.6-1.1之间。胰岛素缺乏时血浆中非酯化脂肪酸的过量可能是该实验性糖尿病模型中动脉变化起始的一个重要因素。
