Reintgen D S, Croker B, Verveart C, Seigler H F
Am J Pathol. 1983 Jul;112(1):1-6.
Because of the technical difficulties encountered with human islet cell transplantation, alternatives toward supplying the juvenile diabetic with an endogenous insulin source are sought. With the use of a streptozotocin-induced diabetic rat model, it was found that by transplantation of a benign insulinoma, the glomerular deposition of material stained by the periodic acid-Schiff method, IgG, IgM, and C3 may be prevented. This effect was found only when transplantation of the insulin-producing tumor occurred within 2-4 weeks of the induction of diabetes. The data suggest that successful insulinoma engraftment can prevent the glomerular mesangial lesions from developing.
由于人类胰岛细胞移植遇到技术难题，人们正在寻找为青少年糖尿病患者提供内源性胰岛素来源的替代方法。利用链脲佐菌素诱导的糖尿病大鼠模型发现，通过移植良性胰岛素瘤，可以防止用高碘酸-希夫氏法染色的物质、IgG、IgM和C3在肾小球沉积。仅当在糖尿病诱导后的2至4周内进行产生胰岛素肿瘤的移植时，才发现这种效果。数据表明，成功的胰岛素瘤植入可防止肾小球系膜病变的发展。
