Radin A M, Black H R
J Am Geriatr Soc. 1981 May;29(5):193-200. doi: 10.1111/j.1532-5415.1981.tb01765.x.
Both pure systolic, and systolic plus diastolic hypertension are risk factors for cerebrovascular and cardiovascular disease in patients over 65 years old, but the efficacy of antihypertensive therapy in preventing the complications of hypertension in the elderly has been questioned. The risks associated with such therapy seem to have been overemphasized. Although the evidence is incomplete, elderly patients should be treated when the systolic blood pressure exceeds 160 mm Hg or the diastolic pressure exceeds 95 mm Hg, or both. A revised stepped-care approach, with use of vasodilating agents as the Step-2 drugs, is proposed.
单纯收缩期高血压以及收缩期加舒张期高血压都是65岁以上患者发生脑血管和心血管疾病的危险因素,但抗高血压治疗在预防老年人高血压并发症方面的疗效一直受到质疑。与这种治疗相关的风险似乎被过度强调了。尽管证据不完整,但当收缩压超过160毫米汞柱或舒张压超过95毫米汞柱,或两者都超过时,老年患者就应该接受治疗。本文提出了一种修订的阶梯式治疗方法,即使用血管扩张剂作为第二步药物。