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无毛小鼠皮肤的渗透作用II:膜切片技术及其对链烷醇渗透性的影响。

Permeation of hairless mouse skin II: membrane sectioning techniques and influence on alkanol permeabilities.

作者信息

Flynn G L, Dürrheim H, Higuchi W I

出版信息

J Pharm Sci. 1981 Jan;70(1):52-6. doi: 10.1002/jps.2600700109.

Abstract

The barrier properties of hairless mouse skin were examined by separating the skin into its component epidermal and dermal strata, using both mechanical and thermal techniques, and then assessing the permeability of each stratum to the homologous alkanols. The permeability data, when compared to those obtained previously for full-thickness hairless mouse skin and to new data for the permeability of the alcohols through a perfect lipid membrane, allow assignment of diffusional resistances to the respective, anatomically distinguishable membrane strata. It was found that the principal barrier for the lower alkanols is the epidermis, which contains the stratum corneum. The effective aqueous tissue resistances of the cellular and aqueous strata of full skin, the epidermis, and the dermis were estimated using sectioned skins. This resistance was much greater than that of an equivalent thickness of water. These data and methods represent a novel approach in the permeation analysis of a biological tissue and offer a means of estimating the effects of skin damage on percutaneous absorption.

摘要

通过机械和热学技术将无毛小鼠皮肤分离为表皮层和真皮层,然后评估各层对同源链烷醇的渗透性,以此来检测无毛小鼠皮肤的屏障特性。将这些渗透性数据与之前从全层无毛小鼠皮肤获得的数据以及醇类透过完美脂质膜的新数据进行比较,可以确定各解剖学上可区分的膜层的扩散阻力。研究发现,低级链烷醇的主要屏障是含有角质层的表皮。使用切片皮肤估计了全皮肤、表皮和真皮的细胞层和水层的有效水性组织阻力。这种阻力远大于同等厚度水的阻力。这些数据和方法代表了生物组织渗透分析中的一种新方法,并提供了一种评估皮肤损伤对经皮吸收影响的手段。

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