Markov Kh M, Kozlov A V, Pinelis V G
Kardiologiia. 1981 Mar;21(3):75-9.
The authors studied the effect of prostacycline and prostaglandins E2 and F2 alpha on the tonus of renal vessels of normotensive rats and rabbits, as well as on the noradrenalin action in the renal and lymph vessels of normotensive and spontaneously hypertensive rats. The effect of prostacycline and prostaglandin E2 proved to be dependent on the type of the animals: in rabbits they reduced, whereas in rats they increased renal perfusion pressure. Indomethacin reduced, while prostaglandin E2 restored the noradrenalin-induced pressor reaction in normotensive rats. In rats with spontaneous hypertension these effects were less pronounced. Prostaglandin F2 alpha increased the pressor effect of noradrenalin both in normotensive and in spontaneously hypertensive rats.
作者研究了前列环素、前列腺素E2和F2α对正常血压大鼠和家兔肾血管张力的影响，以及对正常血压和自发性高血压大鼠肾血管和淋巴管中去甲肾上腺素作用的影响。结果表明，前列环素和前列腺素E2的作用取决于动物种类：在家兔中它们降低肾灌注压，而在大鼠中则升高肾灌注压。消炎痛降低正常血压大鼠中去甲肾上腺素诱导的升压反应，而前列腺素E2可恢复该反应。在自发性高血压大鼠中，这些作用不太明显。前列腺素F2α在正常血压和自发性高血压大鼠中均增强去甲肾上腺素的升压作用。
