Faille A, Maraninchi D, Gluckman E, Devergie A, Balitrand N, Ketels F, Dresch C
Scand J Haematol. 1981 Mar;26(3):202-14. doi: 10.1111/j.1600-0609.1981.tb01648.x.
Bone marrow granulocyte colony forming cells (CFU-C) were measured in HLA compatible sibling donor-recipient pairs. The regeneration of granulocytes and CFU-C compartments were also studied in order to evaluate haemopoietic recovery. The number of nucleated bone marrow cells in the donation was 23 +/- 4 X 10 cells, which recipients received (3.5 +/- 0.4) X 10(8) nucleated cells/kg and (1.19 +/- 0.32) X 10(5) CFU-C/kg. This produced a bone marrow reconstitution of (67 +/- 26) X 10(5) CFU-C/kg by day 30. There was a significant correlation between CFU-C/kg and (1) granulocyte count on day 30 (P equal less than 0.05) and (2) the first day of reappearance of neutrophils in the blood (P equal less than 0.05). These results indicate that the speed and completeness of granulocyte regeneration can be predicted by measurement of the size of the CFU-C inoculant in the bone marrow graft.
在 HLA 配型相合的同胞供受者对中测量骨髓粒细胞集落形成细胞（CFU-C）。为了评估造血恢复情况，还研究了粒细胞和 CFU-C 区室的再生。供体的有核骨髓细胞数量为 23±4×10⁹个细胞，受者接受了（3.5±0.4）×10⁸个有核细胞/千克以及（1.19±0.32）×10⁵个 CFU-C/千克。到第 30 天时，这产生了（67±26）×10⁵个 CFU-C/千克的骨髓重建。CFU-C/千克与（1）第 30 天的粒细胞计数（P 小于 0.05）以及（2）血液中中性粒细胞再次出现的第一天（P 小于 0.05）之间存在显著相关性。这些结果表明，通过测量骨髓移植中 CFU-C 接种物的大小，可以预测粒细胞再生的速度和完整性。
