Emam M, Eichwald E J
Transplantation. 1981 Mar;31(3):156-9. doi: 10.1097/00007890-198103000-00002.
The morphology of first-set rejection of allogeneic murine skin grafts differs strikingly from that usually seen subsequent to sensitization. In the former, graft epithelium appears to be the primary target; in the latter, the endothelium of graft vessels. This difference suggests that different subsets of effector T cells may be involved. This paper reports an attempt to isolate, for further characterization, a T cell population associated with first-set rejection. The relationships between acute and hyperacute rejection of organ transplants and of murine skin grafts are discussed, as is the possible role of endothelium-specific antigens and receptors sites.
同种异体小鼠皮肤移植首次排斥反应的形态与致敏后通常所见的形态显著不同。在前者中，移植上皮似乎是主要靶点；在后者中，移植血管的内皮是主要靶点。这种差异表明可能涉及不同亚群的效应T细胞。本文报道了一项为进一步表征而分离与首次排斥反应相关的T细胞群体的尝试。文中还讨论了器官移植和小鼠皮肤移植的急性排斥反应与超急性排斥反应之间的关系，以及内皮特异性抗原和受体位点的可能作用。
