Karaivanov L, Koleva P, Bonovska M, Mateev M, Kozarev A
Vet Med Nauki. 1980;17(6-7):31-7.
The eliminating effect of rimactan was studied in vivo on resistance markers of E. coli, isolated from 18 new-born pigs with a clinic of enteritis. Rimactan is given per os in 15 mg/kg, liver weight, once a day in the course of 6 days. The sensitivity of the strains eliminated was checked in vitro in respect of 16 medicinal preparations (Pe, Sm, Km, Neo, Chl, Novo, Te, Er, Ty, Sp, Le, Am, Ox, Oxte, Ge-penicillin, streptomycin, kanamycin, neomycin, chlornitromycin, novobiocin, tetracycline, erythromycin, tylan, spectam, lentamycin, ampicillin, oxacillin, oxytetracycline, gentamicin and borgal). To 11 of them E. coli were resistant. After a treatment with rimactan an elimination of resistance markers was observed right on the first day, namely, with regard to Sm, Chl, Novo, Te, Er, Sp, Oxte. On the second day was eliminated the Pe-marker, on the third--the Ty-marker, and it was not until on the fifth day that Am and Ox-markers were eliminated. The elimination frequency was the highest between the third and the fifth days. The experiments studied also the sensitivity of the investigated coli strains with regard to different rimactan concentrations (2-256 mg/cm3) in vitro. It was most pronounced for a concentration of 16-32 mg/cm3. It was proved that rimactan can be used as a preparation for eliminating resistance markers (R-factors) of E. coli in pigs suffering from enteritis.
研究了利马菌素对从18头患有肠炎临床症状的新生仔猪分离出的大肠杆菌耐药标记物的体内消除作用。利马菌素按15毫克/千克肝脏重量经口给药，每天一次，持续6天。对消除后的菌株针对16种药物制剂（青霉素、链霉素、卡那霉素、新霉素、氯硝胺、新生霉素、四环素、红霉素、泰乐菌素、壮观霉素、亮霉素、氨苄青霉素、苯唑西林、土霉素、庆大霉素和博尔加霉素）进行体外敏感性检测。大肠杆菌对其中11种耐药。用利马菌素治疗后，第一天就观察到耐药标记物的消除，即对链霉素、氯硝胺、新生霉素、四环素、红霉素、壮观霉素、土霉素。第二天消除了青霉素标记物，第三天消除了泰乐菌素标记物，直到第五天才消除氨苄青霉素和苯唑西林标记物。消除频率在第三天至第五天最高。实验还研究了所研究的大肠杆菌菌株在体外对不同利马菌素浓度（2 - 256毫克/立方厘米）的敏感性。在浓度为16 - 32毫克/立方厘米时最为明显。证明利马菌素可作为消除患肠炎仔猪大肠杆菌耐药标记物（R因子）的制剂。
