Reznik G, Stinson S F, Ward J M
Arch Toxicol. 1980 Dec;46(3-4):233-40. doi: 10.1007/BF00310439.
Seventy F344 rats and 144 B6C3F1 mice were subdivided into seven groups. Three groups were each exposed via inhalation to 1, 5, or 25 ppm of 1,2-dibromo-3-chloropropane (DBCP) for 6 h per day, 5 days per week for 13 weeks. Three additional groups were each similarly exposed to 3, 15, or 75 ppm of 1,2-Dibromoethane (EDB). The remaining group was exposed to room air under the same conditions. At 13 weeks, rats and mice showed severe necrosis and atrophy of the olfactory epithelium in the nasal cavity after inhalation of 5 or 25 ppm DBCP and 75 ppm EDB. Lower concentrations induced squamous cell metaplasia, hyperplasia and cytomegaly of the epithelium of the respiratory nasal turbinals. Squamous metaplasia, hyperplasia and cytomegaly of the epithelium was also seen in larynx, trachea, bronchi and bronchioles. Other compound related toxic lesions in rats were seen in the liver, kidney and testes.
将70只F344大鼠和144只B6C3F1小鼠分为7组。3组分别通过吸入1、5或25 ppm的1,2 - 二溴 - 3 - 氯丙烷（DBCP），每天6小时，每周5天，持续13周。另外3组分别类似地暴露于3、15或75 ppm的1,2 - 二溴乙烷（EDB）。其余一组在相同条件下暴露于室内空气。13周时，大鼠和小鼠在吸入5或25 ppm DBCP以及75 ppm EDB后，鼻腔内嗅上皮出现严重坏死和萎缩。较低浓度诱导呼吸鼻甲上皮的鳞状细胞化生、增生和细胞肿大。在喉、气管、支气管和细支气管中也可见上皮的鳞状化生、增生和细胞肿大。大鼠中还可见其他与化合物相关的毒性损伤，见于肝脏、肾脏和睾丸。
