Fésüs L, Hársfalvi J, Kovács E, Muszbek L, Stadler I
Biomaterials. 1981 Jan;2(1):53-4. doi: 10.1016/0142-9612(81)90089-2.
The adherence of platelets to collagen fibrils was not affected by prostaglandin I2 (PGI2) applied in a wide concentration range (0.1-100 ng/ml). The retention of platelets on glass beads which includes adhesion as well as subsequent clumping of platelets was, however, greatly reduced at PGI2 concentrations higher than 0.5 ng/ml. The results suggest that PGI2 even at high concentration does not interfere with the primary process of platelet adhesion, i.e., with the formation of a monocellular platelet layer on collagen fibrils and artificial surfaces, but it inhibits clumping of further platelets to this layer and prevents subsequent platelet thrombus formation.
在很宽的浓度范围（0.1 - 100 ng/ml）内应用前列腺素I2（PGI2），血小板与胶原纤维的黏附不受影响。然而，当PGI2浓度高于0.5 ng/ml时，血小板在玻璃珠上的滞留（包括黏附以及随后的血小板聚集）显著降低。结果表明，即使在高浓度下，PGI2也不会干扰血小板黏附的初级过程，即在胶原纤维和人工表面上形成单细胞血小板层，但它会抑制更多血小板聚集到该层，并防止随后的血小板血栓形成。
