Zander A R, Vellekoop L, Spitzer G, Verma D S, Litam J, McCredie K B, Keating M, Hester J P, Dicke K A
Cancer Treat Rep. 1981 May-Jun;65(5-6):377-81.
The combination of high-dose cyclophosphamide, BCNU, and VP-16-213 followed by autologous marrow rescue was evaluated in the treatment of relapsed leukemia refractory to normal-dose chemotherapy. Cyclophosphamide was given at a total dose of 4.5 g/m2, BCNU at a dose of 300 mg/m2, and VP-16-213 at a dose of 600 mg/m2. Seven high-dose treatments followed by marrow rescue were administered to six patients. Two patients achieved complete remissions, three had partial remissions, and one achieved a minimal response. The toxicity of this regimen was moderate.
对高剂量环磷酰胺、卡氮芥和依托泊苷随后进行自体骨髓挽救的联合疗法进行了评估，用于治疗对常规剂量化疗耐药的复发性白血病。环磷酰胺总剂量为4.5 g/m²，卡氮芥剂量为300 mg/m²，依托泊苷剂量为600 mg/m²。对6名患者进行了7次高剂量治疗并随后进行骨髓挽救。2名患者实现完全缓解，3名部分缓解，1名有最小反应。该方案的毒性为中度。
