Morimoto S, Uchida K, Miyamoto M, Kigoshi T, Morise T, Takimoto H, Takeda R
J Am Geriatr Soc. 1981 Jul;29(7):302-7. doi: 10.1111/j.1532-5415.1981.tb01269.x.
The plasma aldosterone (PA) response to sodium restriction (25 mEq daily for 4 days) and to graded infusions of angiotensin II (AII, 2, 4 and 8 ng/kg/min each for 30 min) during a low-sodium intake were studied in 15 elderly subjects with mild essential hypertension versus 10 elderly normotensive subjects. The PA response to sodium restriction relative to changes in plasma renin activity (PRA) was estimated by the ratio of PA increment to PRA increment after sodium restriction (delta PA/delta PRA). THe PA response to graded AII infusions was determined by the increment of PA above the basal level after each dose of AII. In 10 of the 15 elderly hypertensive subjects whose PRAs responded normally to sodium restriction, the delta PA/delta PRA ratios and PA increments during the graded AII infusions were similar to those in the elderly normotensive subjects. However, in the remaining 5 elderly hypertensive subjects whose PRAs responded subnormally to sodium restriction, the delta PA/delta PRA ratios were high and the PA increments greater during the graded AII infusions. THe increments of mean blood pressure during the graded AII infusions were similar in the foregoing 10 of 15 hypertensive subjects, and significantly greater during the AII infusion rates of 4 and 8 ng/kg/min in the remaining 5 hypertensive subjects when compared with those in the normotensive subjects. Apparently some subjects with essential hypertension, whose PRAs response subnormally to sodium restriction, have an abnormally enhanced adrenal responsiveness to AII under the conditions of low-sodium intake.
在低钠摄入期间，对15名轻度原发性高血压老年受试者和10名血压正常的老年受试者，研究了血浆醛固酮（PA）对钠限制（每天25毫当量，共4天）以及对不同剂量血管紧张素II（AII，分别为2、4和8纳克/千克/分钟，各输注30分钟）的反应。通过钠限制后PA增量与血浆肾素活性（PRA）增量的比值（δPA/δPRA）来评估PA对钠限制相对于PRA变化的反应。PA对不同剂量AII输注的反应通过每次AII剂量后PA高于基础水平的增量来确定。在15名老年高血压受试者中，有10名的PRA对钠限制反应正常，其δPA/δPRA比值以及在不同剂量AII输注期间的PA增量与血压正常的老年受试者相似。然而，在其余5名PRA对钠限制反应异常的老年高血压受试者中，δPA/δPRA比值较高，且在不同剂量AII输注期间PA增量更大。在上述15名高血压受试者中的10名中，不同剂量AII输注期间平均血压的增量相似，而其余5名高血压受试者在AII输注速率为4和8纳克/千克/分钟时，与血压正常的受试者相比，平均血压增量显著更大。显然，一些原发性高血压受试者，其PRA对钠限制反应异常，在低钠摄入情况下肾上腺对AII的反应异常增强。
