Tolagen K, Karlberg B E
Acta Med Scand. 1979;205(7):557-62. doi: 10.1111/j.0954-6820.1979.tb06103.x.
Plasma concentrations of angiotensin II (AII) were studied in 36 patients with primary (essential) hypertension and 15 normotensive control subjects during basal (1 h supine rest), upright and frusemide-stimulated (80 mg orally) conditions. Plasma renin activity (PRA) and plasma aldosterone (PA) were determined on the same occasions. AII was then correlated statistically to PRA, PA and 24-hour urinary excretions of aldosterone (Aldo-U), sodium and potassium and to the blood pressure (BP) levels. The AII values in the hypertensive patients were not statistically significantly different from those in the normotensive subjects. A close relationship was found between the AII values and the corresponding PRA values in the hypertensive patients (r=0.65--0.76, p less than 0.001 for all). Correlations between AII and PA, and AII and Aldo-U were not consistently significant. No correlation was found between AII and BP or between AII and 24-hour urinary electrolytes. The findings point to an intact function between PRA and AII but a disturbed AII-aldosterone interrelation in primary hypertension.
在基础状态（仰卧休息1小时）、直立状态以及速尿刺激（口服80毫克）状态下，对36例原发性（特发性）高血压患者和15名血压正常的对照受试者的血浆血管紧张素II（AII）浓度进行了研究。在相同情况下测定血浆肾素活性（PRA）和血浆醛固酮（PA）。然后将AII与PRA、PA、醛固酮24小时尿排泄量（Aldo-U）、钠和钾以及血压（BP）水平进行统计学相关性分析。高血压患者的AII值与血压正常受试者的AII值在统计学上无显著差异。高血压患者的AII值与相应的PRA值之间存在密切关系（r = 0.65 - 0.76，所有p均小于0.001）。AII与PA以及AII与Aldo-U之间的相关性并不始终显著。未发现AII与BP之间或AII与24小时尿电解质之间存在相关性。这些发现表明原发性高血压患者中PRA与AII之间功能完整，但AII - 醛固酮相互关系紊乱。
