Oakley N, Mather H, Hadley L, Lynch J, Pilkington T
J R Soc Med. 1981 May;74(5):363-7. doi: 10.1177/014107688107400508.
Diurnal glucose profiles have been compared in ten insulin dependent diabetics receiving, firstly, a twice-daily soluble insulin (SI): isophane insulin (NPHI) insulin (30% SI, 70% NPHI). For each patient the two regimens gave similar profiles though nocturnal blood glucose control was better on Mixtard. HbA1 values were similar on the two regimens. The findings show that, using highly purified formulations, small changes in insulin proportions in twice-daily SI: NPHI regimens may be irrelevant to diabetic control; they also suggest that highly purified NPHI may have a substantially shorter duration of action than its older counterpart and that the convenient regimen of twice-daily Mixtard is usually as good as any more complicated 'tailormade' regimen of highly purified insulins.
对10名胰岛素依赖型糖尿病患者的日间血糖情况进行了比较，这些患者首先接受每日两次的可溶性胰岛素（SI）：低精蛋白胰岛素（NPHI）胰岛素（30% SI，70% NPHI）。对每位患者而言，两种治疗方案的血糖情况相似，不过在使用优泌林治疗时夜间血糖控制更好。两种治疗方案的糖化血红蛋白（HbA1）值相似。研究结果表明，使用高纯度制剂时，每日两次的SI：NPHI治疗方案中胰岛素比例的微小变化可能与糖尿病控制无关；这些结果还表明，高纯度NPHI的作用持续时间可能比其旧剂型短得多，而且每日两次使用优泌林这种便捷的治疗方案通常与任何更复杂的高纯度胰岛素“定制”方案效果相当。
