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在大肠杆菌的温度敏感型dnaA突变体中，萘啶酸对DNA合成进行暂时抑制后染色体的复制

Chromosome replication following a temporary inhibition of DNA-synthesis by nalidixic acid in a temperature-sensitive dnaA mutant of Escherichia coli.

作者信息

Khachatourians G G

出版信息

Mol Gen Genet. 1981;181(3):411-3. doi: 10.1007/BF00425623.

DOI:10.1007/BF00425623
PMID:7017351
Abstract

Chromosome replication cycle in a DNA initiation mutant of Escherichia coli (CRT-83, dnaAts) was blocked by nalidixic acid, an inhibitor of the A subunit of DNA gyrase. Following a period of inhibition of DNA synthesis, the drug was removed and "run-out" DNA synthesis was examined. It was found that the "capacity" for DNA synthesis was not affected by such a treatment.

摘要

在大肠杆菌的一个DNA起始突变体（CRT - 83，dnaAts）中，染色体复制周期被萘啶酸（一种DNA回旋酶A亚基的抑制剂）阻断。在一段DNA合成受抑制的时期后，去除药物并检测“耗尽型”DNA合成。发现DNA合成的“能力”不受这种处理的影响。

相似文献

1
Chromosome replication following a temporary inhibition of DNA-synthesis by nalidixic acid in a temperature-sensitive dnaA mutant of Escherichia coli.在大肠杆菌的温度敏感型dnaA突变体中，萘啶酸对DNA合成进行暂时抑制后染色体的复制
Mol Gen Genet. 1981;181(3):411-3. doi: 10.1007/BF00425623.
2
Requirement of DNA gyrase for the initiation of chromosome replication in Escherichia coli K-12.大肠杆菌K-12中染色体复制起始对DNA促旋酶的需求
Mol Gen Genet. 1980 Jan;177(2):301-9. doi: 10.1007/BF00267443.
3
Transient DNA relaxation in Escherichia coli induced by nalidixic acid.萘啶酸诱导大肠杆菌中的瞬时DNA松弛
Biol Pharm Bull. 1997 May;20(5):467-70. doi: 10.1248/bpb.20.467.
4
Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme.萘啶酸的作用机制：大肠杆菌nalA基因产物的纯化及其与DNA回旋酶和一种新型切口封闭酶的关系。
Proc Natl Acad Sci U S A. 1977 Nov;74(11):4767-71. doi: 10.1073/pnas.74.11.4767.
5
Inhibitors of DNA synthesis cause excessive DNA synthesis in dnaA mutants of Escherichia coli K12.
Can J Microbiol. 1978 Oct;24(10):1250-2. doi: 10.1139/m78-200.
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Effect of nalidixic acid on recombination and DNA repair of Escherichia coli K-12 strains.萘啶酸对大肠杆菌K-12菌株重组及DNA修复的影响。
Indian J Exp Biol. 1996 Oct;34(10):949-53.
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Gyrase-dependent initiation of bacteriophage T4 DNA replication: interactions of Escherichia coli gyrase with novobiocin, coumermycin and phage DNA-delay gene products.噬菌体T4 DNA复制的依赖于回旋酶的起始：大肠杆菌回旋酶与新生霉素、香豆霉素及噬菌体DNA延迟基因产物的相互作用
J Mol Biol. 1979 Jan 25;127(3):265-83. doi: 10.1016/0022-2836(79)90329-2.
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Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity.萘啶酸抗性：参与DNA回旋酶活性的第二个遗传特征。
Proc Natl Acad Sci U S A. 1977 Nov;74(11):4772-6. doi: 10.1073/pnas.74.11.4772.
9
Nalidixic acid-sensitive and resistant modes of DNA replication in Escherichia coli.大肠杆菌中DNA复制的萘啶酸敏感和抗性模式。
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10
[Temperature-sensitive mutant Escherichia coli for the B-subunit of DNA-gyrase. The effect on replication and transcription].[DNA促旋酶B亚基的温度敏感型突变大肠杆菌。对复制和转录的影响]
Genetika. 1983 Mar;19(3):425-34.

本文引用的文献

1
[Thermosensitive mutants of Escherichia coli K 12. I. Isolation and rapid characterization].[大肠杆菌K12的热敏突变体。I. 分离与快速鉴定]
Ann Inst Pasteur (Paris). 1966 Apr;110(4):465-86.
2
Interaction between DNA and an Escherichia coli protein omega.DNA与大肠杆菌蛋白ω之间的相互作用。
J Mol Biol. 1971 Feb 14;55(3):523-33. doi: 10.1016/0022-2836(71)90334-2.
3
On the process of cellular division in Escherichia coli. 3. Thermosensitive mutants of Escherichia coli altered in the process of DNA initiation.关于大肠杆菌细胞分裂的过程。3. 在DNA起始过程中发生改变的大肠杆菌温度敏感突变体。
J Mol Biol. 1970 Nov 14;53(3):369-87. doi: 10.1016/0022-2836(70)90072-0.
4
On the process of cellular division in Escherichia coli. Membrane prtein alterations associated with mutations affecting the initiation of DNA synthesis.关于大肠杆菌细胞分裂过程。与影响DNA合成起始的突变相关的膜蛋白改变。
J Mol Biol. 1970 Aug 28;52(1):75-89. doi: 10.1016/0022-2836(70)90178-6.
5
DNA synthesis in temperature sensitive mutants of Escherichia coli.大肠杆菌温度敏感突变体中的DNA合成
Cold Spring Harb Symp Quant Biol. 1968;33:317-24. doi: 10.1101/sqb.1968.033.01.036.
6
Regulation of deoxyribonucleic acid replication and cell division in Escherichia coli B-r.大肠杆菌B-r中脱氧核糖核酸复制与细胞分裂的调控
J Bacteriol. 1968 Oct;96(4):1214-24. doi: 10.1128/jb.96.4.1214-1224.1968.
7
Cell division during inhibition of deoxyribonucleic acid synthesis in Escherichia coli.大肠杆菌中脱氧核糖核酸合成受抑制时的细胞分裂
J Bacteriol. 1968 May;95(5):1627-33. doi: 10.1128/jb.95.5.1627-1633.1968.
8
Relationship between nucleoside triphosphate pools and DNA replication in the cell cycle of Escherichia coli.
Can J Microbiol. 1974 May;20(5):747-50. doi: 10.1139/m74-113.
9
Analysis of cell division in rapidly growing synchronous cultures of Escherichia coli recovering from an inhibition of deoxyribonucleic acid synthesis.对从脱氧核糖核酸合成抑制中恢复的快速生长的同步培养大肠杆菌细胞分裂的分析。
Can J Microbiol. 1973 Sep;19(9):1111-4. doi: 10.1139/m73-176.
10
On the structure of the folded chromosome of Escherichia coli.关于大肠杆菌折叠染色体的结构
J Mol Biol. 1972 Nov 14;71(2):127-47. doi: 10.1016/0022-2836(72)90342-7.