Oney T, Beer A, Kaulhausen H
Obstet Gynecol. 1981 Jul;58(1):31-4.
Plasma renin activity and aldosterone concentration were determined radioimmunologically after 30 minutes in the left lateral position and after an additional 30 minutes of supine recumbency in 26 normotensive nulliparous women between 28 and 32 weeks' gestation. Plasma renin activity decreased slightly but significantly in the supine position (P less than .05). A distinct increase of plasma aldosterone was observed in 14 of the 26 subjects. The following speculation has been drawn from these results: the fetal renin-angiotensin system is activated by decreased uteroplacental perfusion in the supine position, possibly followed by a diminution of blood flow to the fetal kidney, perhaps via hypoxia. Subsequently, aldosterone may also be secreted by the fetus at an increased rate. In contrast to the high molecular weight renin, aldosterone passes the placental barrier and appears in the maternal circulation.
对26名孕28至32周的血压正常未生育女性，左侧卧位30分钟后及再仰卧位30分钟后，采用放射免疫法测定血浆肾素活性和醛固酮浓度。仰卧位时血浆肾素活性略有下降但差异有统计学意义（P<0.05）。26名受试者中有14名观察到血浆醛固酮明显升高。从这些结果得出以下推测：仰卧位时子宫胎盘灌注减少激活胎儿肾素-血管紧张素系统，可能随后胎儿肾血流量减少，或许是通过缺氧途径。随后，胎儿醛固酮分泌速率也可能增加。与高分子量肾素不同，醛固酮可通过胎盘屏障并出现在母体循环中。
